Dopaminergic D1 and D2 Receptors Are Essential for the Arousal Effect of Modafinil
نویسندگان
چکیده
منابع مشابه
Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil.
Modafinil is a wake-promoting compound with low abuse potential used in the treatment of narcolepsy. Although the compound is reported to affect multiple neurotransmitter systems such as catecholamines, serotonin, glutamate, GABA, orexin, and histamine, however, the molecular mechanism by which modafinil increases wakefulness is debated. Herein we used dopamine (DA) D(2) receptor (D(2)R)-defici...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2008
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1819-08.2008